Opiates have a very high addictive potential because they stimulate opioid receptors and the reward system in the brain, and also increase the release of endorphins. This creates a feeling of well-being, and when the effects of the opiates wear off, there is an indescribable urge to reintroduce yourself to a blissful and euphoric state – thus creating a psychological addiction to opiates. As opioid use multiplies, physical dependence develops. Opioids are incorporated into human metabolic processes. The structure of the brain changes, and the body demands more doses of the drug. When trying to stop taking opiates, the opioid withdrawal syndrome occurs, which is associated with a number of very unpleasant symptoms, some of which are dangerous to health and life.